Gert Fricker Selected Research

Member 1 Subfamily B ATP Binding Cassette Transporter

11/2022	Sodium arsenite but not aluminum chloride stimulates ABC transporter activity in renal proximal tubules of killifish (Fundulus heteroclitus).
4/2022	Re-evaluation of the hCMEC/D3 based in vitro BBB model for ABC transporter studies.
1/2019	Impact of Zn2+ on ABC Transporter Function in Intact Isolated Rat Brain Microvessels, Human Brain Capillary Endothelial Cells, and in Rat in Vivo.
1/2019	Aryl hydrocarbon receptor ligands increase ABC transporter activity and protein expression in killifish (Fundulus heteroclitus) renal proximal tubules.
11/2017	Zinc chloride rapidly stimulates efflux transporters in renal proximal tubules of killifish (Fundulus heteroclitus).
6/2015	Genomic Knockout of Endogenous Canine P-Glycoprotein in Wild-Type, Human P-Glycoprotein and Human BCRP Transfected MDCKII Cell Lines by Zinc Finger Nucleases.
8/2014	Cytotoxicity and inhibition of P-glycoprotein by selected medicinal plants from Thailand.
9/2013	Dynamic regulation of P-glycoprotein in human brain capillaries.
7/2010	Inhibition of P-glycoprotein at the blood-brain barrier by phytochemicals derived from traditional Chinese medicine.
2/2009	Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the p-glycoprotein (ABCB1) modulator tariquidar.

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Gert Fricker Research Topics

Disease

22	Neoplasms (Cancer) 03/2023 - 02/2002
14	Breast Neoplasms (Breast Cancer) 01/2023 - 07/2008
9	Alzheimer Disease (Alzheimer's Disease) 02/2024 - 10/2015
7	Brain Neoplasms (Brain Tumor) 01/2023 - 12/2003
5	Infections 02/2024 - 05/2011
3	Inflammation (Inflammations) 02/2024 - 01/2022
3	Glioma (Gliomas) 12/2023 - 12/2003
3	Central Nervous System Diseases (CNS Diseases) 01/2022 - 10/2010
3	Leukemia 08/2014 - 11/2007
2	Neoplasm Metastasis (Metastasis) 01/2023 - 01/2018
2	Liver Diseases (Liver Disease) 09/2022 - 04/2014
2	Cryptococcal Meningitis 05/2017 - 10/2015
2	Epilepsy (Aura) 05/2016 - 09/2013
1	Lewy Body Disease (Lewy Body Dementia) 02/2024
1	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2023
1	Cognitive Dysfunction 12/2023
1	Tauopathies 12/2023
1	Ulcerative Colitis 03/2023
1	Disease Progression 01/2023
1	Hypoxia (Hypoxemia) 01/2023
1	Renal Insufficiency (Renal Failure) 01/2023
1	Triple Negative Breast Neoplasms 01/2023
1	Kidney Diseases (Kidney Disease) 01/2023
1	Neuroinflammatory Diseases 01/2022
1	Melanoma (Melanoma, Malignant) 06/2021
1	Lymphatic Metastasis 06/2021
1	Non-alcoholic Fatty Liver Disease 01/2020
1	Fatty Liver 01/2020
1	Gastroesophageal Reflux (GERD) 01/2020
1	Liver Cirrhosis (Hepatic Cirrhosis) 01/2020
1	Hepatocellular Carcinoma (Hepatoma) 01/2020
1	Fibrosis (Cirrhosis) 11/2019
1	Alcoholic Fatty Liver 11/2019
1	Carcinogenesis 01/2019

Drug/Important Bio-Agent (IBA)

22	Proteins (Proteins, Gene)FDA Link 02/2024 - 07/2008
14	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 11/2022 - 02/2002
5	Peptides (Polypeptides)IBA 02/2023 - 07/2018
4	LigandsIBA 01/2023 - 07/2018
3	Transferrin Receptors (Transferrin Receptor)IBA 02/2024 - 10/2015
3	Membrane Transport Proteins (Biological Pump)IBA 01/2024 - 01/2022
3	ATP-Binding Cassette Transporters (ABC Transporters)IBA 03/2023 - 10/2010
3	ErbB Receptors (EGF Receptor)IBA 02/2023 - 08/2022
3	IntegrinsIBA 01/2023 - 11/2019
2	Chelating AgentsIBA 02/2023 - 10/2022
2	Adenosine Triphosphate (ATP)IBA 02/2023 - 01/2019
2	LipopolysaccharidesIBA 11/2022 - 01/2022
2	essential 303 forteIBA 09/2022 - 01/2020
2	Phospholipids (Phosphatides)FDA LinkGeneric 01/2020 - 11/2019
2	Multidrug Resistance-Associated ProteinsIBA 01/2019 - 07/2008
2	Tyrosine Kinase InhibitorsIBA 01/2018 - 01/2017
2	Itraconazole (Sporanox)FDA LinkGeneric 05/2017 - 10/2015
2	Phosphotransferases (Kinase)IBA 01/2017 - 01/2017
2	TropomyosinIBA 01/2017 - 01/2017
2	AntibodiesIBA 09/2016 - 10/2015
2	Carrier Proteins (Binding Protein)IBA 09/2015 - 01/2011
2	indirubinIBA 11/2013 - 10/2013
2	Fluorescein (Funduscein)FDA LinkGeneric 07/2009 - 12/2003
1	rasagiline (Azilect)FDA Link 02/2024
1	Apolipoproteins E (ApoE)IBA 12/2023
1	Prolyl OligopeptidasesIBA 12/2023
1	4-phenylbutanoyl-prolylcyanopyrrolidineIBA 12/2023
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 12/2023
1	tau Proteins (tau Protein)IBA 12/2023
1	Protein Phosphatase 2 (Protein Phosphatase 2A)IBA 12/2023
1	MetalsIBA 03/2023
1	PlatinumIBA 03/2023
1	Peptide Hydrolases (Proteases)FDA Link 02/2023
1	Amino Acid Transport Systems (Amino Acid Transporter)IBA 02/2023
1	ProdrugsIBA 01/2023
1	GE11 peptideIBA 01/2023
1	G(A1) ganglioside (GA(1))IBA 01/2023
1	Monoacylglycerol LipasesIBA 01/2023
1	Member 2 Subfamily G ATP Binding Cassette TransporterIBA 01/2023
1	Small Interfering RNA (siRNA)IBA 01/2023
1	regorafenibIBA 01/2023
1	resazurinIBA 01/2023
1	Iopamidol (Isovue)FDA LinkGeneric 01/2023
1	cobaltous chloride (cobalt(II)chloride)IBA 01/2023
1	Aluminum ChlorideIBA 11/2022
1	Cetuximab (Erbitux)FDA Link 10/2022
1	Type 1 Melanocortin ReceptorIBA 06/2021
1	RadiopharmaceuticalsIBA 07/2020
1	SugarsIBA 01/2020
1	AntacidsIBA 01/2020
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2020
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 01/2020
1	AlginatesIBA 01/2020
1	LipidsIBA 01/2020
1	sodium bicarbonate drug combination magnesium trisilicate aluminium hydroxide alginate (Gaviscon)FDA Link 01/2020
1	Bile Acids and Salts (Bile Acids)IBA 11/2019
1	LysophospholipidsIBA 11/2019
1	ursodeoxycholyl lysophosphatidylethanolamideIBA 11/2019
1	Polychlorinated Dibenzodioxins (TCDD)IBA 01/2019
1	XenobioticsIBA 01/2019
1	Bombesin Receptors (Bombesin Receptor)IBA 07/2018
1	Neuropeptide Y Receptors (Neuropeptide Y Receptor)IBA 07/2018

Therapy/Procedure

10	Therapeutics 02/2023 - 07/2010
4	Drug Therapy (Chemotherapy) 03/2023 - 02/2005
2	Chinese Traditional Medicine (Traditional Chinese Medicine) 11/2013 - 10/2013
1	Oral Administration 02/2024